主持多项国家省部级项目，发表SCI论文80余篇，参编著作2部，授权专利6项。Contrast Media & Molecular Imaging 的客座编辑，Molecular Pharmaceutics、Oncotarget、Theranostics 、Food and Function、Phytomedicine等杂志审稿人。

近三年在国内外核心期刊上发表学术论文情况

2018年

1. Qiaomei Jin#, Xin Shan#, Qi Luoa,Dongjian Zhang,Yuanyu Zhao, Nan Yao, Fei Peng, Dejian Huang, Zhiqi Yin,Wei Liu*, Jian Zhang* . ¹³¹I-Evans blue: evaluation of necrosis targeting property and preliminary assessment of the mechanism in animal models. Acta Pharmaceutica Sinica B. 2018;8(3):390–400
2. Huimin Yang, Zhiqi Yin, Mengge Zhao, Cuihua Jiang, Jian Zhang*，Ke Pan*. Pentacyclic triterpenoids from Cyclocarya paliurus and their antioxidant activities in FFA-induced HepG2 steatosis cells. Phytochemistry. 2018,151:119-127
3. Ke Ren , Jian Zhang , Xiaojie Gu , Sujia Wu , Xin Shi , Yicheng Ni , Yong Chen , Jun Lu ,Zengxin Gao, Chen Wang, Nan Yao*. Migration-inducing gene-7 independently predicts poor prognosis of human osteosarcoma and is associated with vasculogenic mimicry. Experimental cell research. 2018;369(1):80-89
4. Qiaomei Jin, Jian Zhang, Cuihua Jiang, Dongjian Zhang, Meng Gao, Shihe Hu*. Self [3 + 4] Cycloadditions of Isatin N,N# -Cyclic Azomethine Imine 1,3 -Dipole with N-(ortho-Chloromethyl)aryl Amides. The Journal of Organic Chemistry. 2018;83(15):8410-8416
5. Li Bian, Meng Gao, Dongjian Zhang, Aiyan Ji, Chang Su, Xinghua Duan,Qi Luo, Dejian Huang, Yuanbo Feng Yicheng Ni, Zhiqi Yin, Qiaomei Jin*, Jian Zhang*. Synthesis and Biological Evaluation of Rhein-Based MRI Contrast Agents for in Vivo Visualization of Necrosis. Analytical chemistry. 2018, 90(22):13249-13256.
6. Jiajia Liang#, Qi Luo#, Dongjian Zhang, Qiaomei Jin, Lichao Liu, Wei Liu, Meng Gao, Jian Zhang*, Zhiqi Yin*. SPECT Imaging of Treatment-Related Tumor Necrosis Using Technetium-99m-Labeled Rhein. Mol Imaging Biol. 2018, 1536-1632
7. Mengge Zhao, Xueping Sheng, Yaping Huang, Yiting Wang, Cuihua Jiang*, Jian Zhang*, Zhi qi Yin*. Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates nonalcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction. Biomedicine & Pharmacotherapy. 2018，104:229-239.
8. Jiajia Liang, Ziping Sun, Dongjian Zhang, Qiaomei Jin, Lingqiao Cai, Lin Ma, Wei Liu, Yicheng Ni, Jian Zhang*, Zhiqi Yin*. First Evaluation of Radioiodinated Flavonoids as Necrosis-Avid Agents and Application in Early Assessment of Tumor Necrosis. Molecular Pharmaceutics. 2018, 15: 207-215
9. Chang Su, Dongjian Zhang, Na Bao, Aiyan Ji,  Yuanbo Feng,  Li Chen,  Yicheng Ni,  Jian Zhang*, Zhiqi Yin*. Evaluation of radioiodinated 1, 4-naphthoquinones as necrosis avid agents for rapid myocardium necrosis imaging. Molecular imaging and biology. 2018, 20(1): 74-84
10. Qiaomei Jin*, Jian Zhang, Shihe Hu*. Tributylphosphane-promoted [3 +2] annulation of 3-hydroxyoxindoles with acrylates: Synthesis of spirocyclic oxindole-lactones. Journal of Saudi Chemical Society. 2018, 22: 27-33；
11. Qiaomei Jin#， Juanzhi Zhao#， Meng Gao， Yuanbo Feng， Wei Liu， Zhiqi Yin, Tiannv Li, Shaoli Song， Yicheng Ni， Jian Zhang， *Dejian Huang，* Dongjian Zhang. Evaluation of Necrosis Avidity and Potential for Rapid Imaging of Necrotic Myocardium of Radioiodinated Hypocrellins. Molecular imaging and biology. 2018, DOI:10.1007/s11307-017-1157-
12. Qiaomei Jin, Meng Gao, Dongjian Zhang, Cuihua Jiang, Nan Yao, Jian Zhang. Base-mediated [2 + 4] cycloadditions of in situ formed azaoxyallyl cations with N-(2-chloromethyl)aryl amides. Organic & Biomolecular Chemistry. 2018, 16, 7336

2017

13. Aiyan Ji, Qiaomei Jin, Dongjian Zhang, Hua Zhu, Chang Su, Xinghua Duan, Li Bian, Ziping Sun, Yicheng Ni, Jian Zhang*, Zhi Yang*, Zhiqi Yin*. Novel 18F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging. ACS Medicinal chemistry letters. 2017, 8(2): 191-195
14. Qi Luo, Qiaomei Jin, Chang Su, Dongjian Zhang, Cuihua Jiang, Anne Folta Fish, Yuanbo Feng, Yicheng Ni,  Jian Zhang* , Zhiqi Yin*. Radiolabeled Rhein as Novel Small-Molecule Necrosis Avid Agents for Rapid Imaging of Necrotic Myocardium. Analytical chemistry. 2017, 89(2): 1260-1266
15. Xinghua Duan#, Zhiqi Yin#, Cuihua Jiang, Qiaomei Jin, Dongjian Zhang, Ziping Sun , Wencai Ye*, Jian Zhang*. Radioiodinated Hypericin Disulfonic acid Sodium Salts as a DNA-Binding Probe for Early Imaging of Necrotic Myocardium. European Journal of Pharmaceutics. 2017, 117: 151-159
16. Zhengfeng# Wu, Tianhong Gao#, Rongling Zhong, Zi Lin, Cuihua Jiang, Sheng Ouyang, Ming Zhao, Chuntao Che, Jian Zhang*, Zhiqi Yin*. Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats. Pharmaceutical biology. 2017, 55(1): 712-721
17. Nan Yao#,  Ke Ren#， Yimin Wang， Qiaomei Jin，Xiao Lu，Yan Lu，Cuihua Jiang,， Dongjian Zhang,，Jun Lu，Chen Wang，Jiege Huo， Yong Chen*， Jian Zhang*. Paris polyphylla Suppresses Proliferation and Vasculogenic Mimicry of Human Osteosarcoma Cells and Inhibits Tumor Growth In Vivo. The American Journal of Chinese Medicine. 2017, 45(3): 575-598
18. Zhiqi Yin#, Lidan Sun#, Qiaomei Jin, Shaoli Song, Yuanbo Feng, Hong Liao, Yicheng Ni, Jian Zhang*, Wei Liu*. Excretion and toxicity evaluation of 131I-Sennoside A as a necrosis-avid agent. Xenobiotica. 2017, 47(11): 980-988.
19. Zhengfeng Wu#, Fancheng Meng#, Lanjie Cao, Cuihua Jiang , Mengge Zhao, Xulan Shang , Shengzuo Fang , Wencai Ye , Qingwen Zhang, Jian Zhang*,  Zhiqi Yin*. Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells. Phytochemistry. 2017, 142: 76-84
20. 卞丽, 高萌, 黄德健, 彭飞, 张健*, 殷志琦*. 坏死亲和性MRI对比剂 Gd-DO3A-rhein的合成及其靶向性. 中国药科大学学报. 2017, 48(3)：282-288

2016

21. Meng Gao, Dongjian Zhang, Qiaomei Jin, Cuihua Jiang, Cong Wang, Jindian Li, Fei Peng, Dejian Huang, Jian Zhang*, Shaoli Song*. Combretastatin-A4 phosphate improves the distribution and antitumor efficacy of albumin-bound paclitaxel in W256 breast carcinoma model. Oncotarget. 2016, 7(36): 58133-58141
22. Ling Li, Dongjian Zhang, Shengwei Yang, Shaoli Song, Jindian Li, Qin Wang, Cong Wang, Yuanbo Feng, Yicheng Ni, Jian Zhang*, Wei Liu*, Zhiqi Yin*. Effects of Glycosylation on Biodistribution and Imaging Quality of Necrotic Myocardium of Iodine-131-Labeled Sennidins.Molecular Imaging and Biology. 2016, 18(6): 877-886
23. Haiyan Zhou, Meng Li, Jian Qu, Su Jing*, Heng Xu*, Juanzhi Zhao, Jian Zhang, Mingfang He. Effective Antitumor Candidates Based upon Ferrocenylseleno-Dopamine Derivatives: Growth Inhibition by Induction Cell Apoptosis and Antivascular Effects. Organometallics. 2016, 35(11): 1866-1875
24. Weiwen Hu, Jian Zhang*, Jinming Kong*. Fluorescence detection of DNA based on non-covalent π-π stacking interaction between 1-pyrenebutanoic acid and hypericin. Analytical Science. 2016, 32(5): 523-527
25. Zi Lin, Zhengfeng Wu, Cuihua Jiang, Qing-Wen Zhang, Sheng Ouyang， Chuntao Che, Jian Zhang, Zhiqi Yin*. The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. Phytomedicine, 2016, 23(12): 1475-1483
26. Marlein Miranda Cona, Yewei Liu, Antoine Hubert, Ting Yin, Yuanbo Feng, Peter de Witte, Etienne Waelkens, Yansheng Jiang, Jian Zhang, Stefaan Mulier, Qian Xia, Gang Huang, Raymond Oyen, Yicheng Ni*. Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent. World J Gastroenterol. 2016, 22(29): 6690-705
27. Marlein Miranda Cona, Yewei Liu, Ting Yin, Yuanbo Feng, Feng Chen, Stefaan Mulier, Yue Li, Jian Zhang, Raymond Oyen, Yicheng Ni*. Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder. World J Methodol. 2016, 6(2): 154-162
28. Qin Wang, Shengwei Yang, Cuihua Jiang, Jindian Li, Cong Wang, Linwei Chen, Qiaomei Jin,  Shaoli Song, Yuanbo Feng, Yicheng Ni, Jian Zhang*, Zhiqi Yin^*. Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. Scientific Reports, 2016, 6: 21341. (IF=5.578)
29. Cong Wang, Qiaomei Jin, Shengwei Yang, Dongjian Zhang, Qin Wang, Jindian Li, Shaoli Song, Ziping Sun,Yicheng Ni, Jian Zhang^*, Zhiqi Yin^*. Synthesis and Evaluation of 131I-skyrin as a Necrosis Avid Agent for Potential Targeted Radionuclide Therapy of Solid Tumors. Molecular Pharmaceutics. 2016, 13(1): 180-189.   (IF=4.384)
30. Jindian Li^#, Jian Zhang^#, Shengwei Yang, Cuihua Jiang, DongJian Zhang, Qiaomei Jin,  Qin Wang, Cong Wang, Yicheng Ni, Zhiqi Yin^*, Shaoli Song^*. Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses. Molecular Pharmaceutics. 2016, 13(1):  232-240.     (IF=4.384)
31. Zhiqi Yin^#*, ShuLe Yu^#, YuJian Wei, Lin Ma, ZhengFeng Wu, Lei Wang, QingWen Zhang, Ming Zhao, WenCai Ye, ChunTao Che, Jian Zhang^*. C₂₁ Steroidal Glycosides from Cynanchum stauntonii Induce Apoptosis in HepG2 Cells. Steroids, 2016,106: 55-61

在研课题列表

333人才项目（高层次卫生人才“六个一工程”拔尖人才项目）LGY2018075 基于金丝桃素构建靶向死亡细胞磁共振分子探针评价肿瘤近期疗效及其机制研究。2019.1.1-2021.1.1

六大人才高峰高层次人才项目 YY-011  构建中位二蒽酮类分子探针靶向E-DNA用于心肌活性评价研究，2018/01-2020/12，5万元

江苏省自然基金 20171512  基于金丝桃素构建靶向死亡细胞的磁共振分子探针评价肿瘤近期疗效及作用机制研究，2017/06-2019/05, 10万元

国家自然科学面上基金81771870  131I-金丝桃素靶向坏死肿瘤清除肝癌动脉栓塞后残留病灶及其机制研究，2018/01-2021/12，55万元