导师风采

瞿鼎

专业代码:100800

专业名称:中药学

学术/专业型:学术型

职务

  • 博士生导师

—— 个人简介 ——


  瞿鼎男,1985.05,博士江苏省中医药研究院研究员,南京中医药大学士生导师,江苏省333高层次人才”,江苏省“六大人才高峰” 江苏省医学青年重点人才”,马萨诸塞州州立大学医学院高级访问学者江苏省新型产业研究院评审专家,江苏省科技系统专家库成员、高新技术企业认定专家库成员。兼任世中联中药制剂委员会常务理事;中华中医药学会中成药分会委员,中华中医药学会李时珍分会委员中国颗粒学会青年理事,中国民族药学会经皮治疗分会常务理事,江苏省颗粒学会理事,江苏省中西医学会中西医结合肿瘤治疗分委会委员兼任针灸与草药(英文)》青年编委、Brain-X”特约编辑、《中草药》、《中国医院药学杂志》青年编委。长期担任《中国医院药学杂志》、《中国中药杂志》Journal of Controlled ReleaseActa Biomaterialia”,“ACS Applied Materials&InterfacesAdvanced Healthcare Materials Advanced Functional Materials等国内外期刊独立审稿人。目前研究方向:1. 中药多组分新型药物递送系统抗肿瘤、抗老年性相关视网膜等疾病的临床前研究2. 通用型纳米乳剂增溶技术的新药研发与产业化研究;3. 功能化无机纳米粒化学免疫治疗肿瘤的临床/临床前研究。主持国家自然科学基金3项)、江苏省社会发展重点研发计划(1项)、江苏省自然科学基金2项)、中国中医科学院中央级公益专项、江苏省医学青年重点人才项目10余项省部级以上科研项目。现发表国内外学术论文60余篇,其中以第一/通讯作者身份发表Biomaterials research Carbohydrate PolymersJournal of nanobiotechnology ACS Applied Materials & Interfaces International Journal of Biological MacromoleculesSCI论文30余篇,平均影响因子>8.0,总被引1000余次,h指数22google,截止20232月)。申请国家发明专利12项,PCT国际专利1项,相关成果已获2019年江苏省医学科技奖一等奖、2015年江苏中医药科学技术一等奖、2015年中华中医药科学技术二等奖、2021年湖南省中医药科技一等奖等。


近五年主持在研课题:

[1] 国家自然科学基金面上项目(82173980),《光控式原位水凝胶药库视网膜自主递送大黄酸&黄芩苷协同治疗AMD研究》,2022/01-2024/1254万,在研、负责人;

[2] 国家自然科学面上基金,81873017,《可靶向调控TAMs极化的灵芝酸A化学免疫给药系统用于乳腺癌联合治疗研究》,2019/01 – 2022/1257万、结题、负责人;

[3] 江苏省社会发展重点研发计划面上项目(BE2023788),《可向视网膜持续递药的玻璃体注射型水凝胶的技术攻关及联合VEGF-A单抗治疗湿性年龄相关性黄斑变性的优效性研究》,2023/09-2026/1050万,在研、负责人;

[4] 江苏省自然科学基金面上项目(BK20211389),《光控释原位水凝胶药库视网膜自主递送川芎嗪&芍药苷协同治疗AMD研究》,2021/07-2024/0610万,在研、负责人;

[5] 江苏省中医药管理局重点项目ZD202322),《内置气囊型可溶微针共载补骨脂素和雷公藤红素协同治疗骨关节炎研究》,2023/09-2026/0843万,在研、负责人;

[6] 江苏省医学青年人才项目专项基金,QNRC2016631基于肿瘤微环境调控释放策略构建的中药脂质复合物系统逆转肿瘤多药耐药研究2016/01 – 2020/1225万、已结题、负责人。

[7] 江苏省六大人才高峰项目,YY-028-2019中药多组分新型给药系统化学-免疫联合抗肿瘤研究2019/06 – 2022/064万、在研、负责人。

[8] 江苏省中医药研究院重点科研专项,BM-2018024-2019002基于肿瘤免疫激活信号放大策略设计的中药多组分MOF协同治疗乳腺癌研究2019/01 – 2022/1220万、结题、负责人。

[9] 南京中医药大学双一流建设科研专项,2020YLXK015中药多糖新型给药系统免疫激活肿瘤微环境治疗乳腺癌研究2020/11 – 2022/1120万、结题、负责人。


授权专利:

[1] 瞿鼎,等. 富血小板血浆的泡腾型可溶微针贴片及其制备方法,202211433516.62022年新申请)

[2] 瞿鼎,等. 一种用于微乳制剂的油相调配方法及其应用,202211178415.92022年新申请)

[3] 瞿鼎,刘聪燕,陈彦,等. 光敏型玻璃体可注射凝胶及其制备方法和应用,ZL202111546832.X(已授权)

[4] 瞿鼎,等. 前置空泡型大麻脂溶性活性物可溶微针的制备及在浅表性皮肤瘤深层递药的应用,ZL202111587021.4(已授权):

[5] 瞿鼎,陈彦,刘玉萍,刘聪燕,黄萌萌,李晓琦,一种化学免疫干预剂及应用,2019.6,中国,201910485470.4

[6] 瞿鼎,陈彦,黄萌萌,刘玉萍,刘聪燕,一种中药-磁纳米簇化学免疫药物递送系统及其制备方法,2018.8,中国,ZL201810925321.0(已授权);

[7] 一种中药复合温敏凝胶栓塞剂及其制备方法和应用,ZL 202111360930.4,陈彦,史新萌,瞿鼎,刘聪燕,刘玉萍.申请日:2021.11.17,授权日2022.07.01(已授权)

[8] 包载大蒜素的细胞微颗粒载药系统及其制备方法和应用,ZL 202010219886.4,专利发明人:刘玉萍,陈彦,瞿鼎,刘聪燕,申请日期2019.03.25,授权日期:2022.05.20(已授权)

[9] 陈彦,瞿鼎,黄萌萌,刘玉萍,一种由肿瘤微环境控制粒径大小及药物释放的多组分脂质复合系统、其制备方法与制药中的应用,2016.10,中国,ZL201610882317.1 (已授权)

[10] 陈彦,瞿鼎,刘聪燕,中药组分微乳纳米递送系统及其制备方法与在制备药物制剂中的应用,2014.4,中国,ZL201410149584.9(已授权)

[11] 张灿,瞿鼎,曲国威,林海娇,宗莉,肿瘤主动靶向壳聚糖衍生物及其药学应用,2012.11,中国,ZL201210484182.5(已授权)

[12] 瞿鼎,陈彦,刘玉萍,刘聪燕,黄萌萌,李晓琦,一种化学免疫干预剂及应用,2019.6PCT (all designed countries)zbxb1907.

其他成果:

[1] 瞿鼎(1/5),药辅合一式中药组分纳米乳增溶技术的通用化拓展,南京市医学会,2023年南京中医药科技奖,二等奖,2023 (瞿鼎; 陈彦; 张振海; 刘聪燕; 张黄琴);

[2] 瞿鼎(2/8),中药抗肿瘤活性组分新型给药系统的创建,江苏省医学会,2019年江苏医学科技奖,一等奖,2019 (陈彦; 瞿鼎; 刘玉萍; 刘聪燕; 黄萌萌; 张振海; 李晓琦);

[3] 瞿鼎(2/8),抗肿瘤中药微粒多途径传递系统核心技术创研,江苏中医药学会,2015年江苏中医药科学技术奖,一等奖,2015 (陈彦,瞿鼎,张振海,刘聪燕,范晨怡,周静,曹伟,吴青青);

[4] 瞿鼎(2/8),抗肿瘤中药微粒多途径传递系统核心技术创研,中华中医药学会,2015年中华中医药学会科学技术奖,二等奖,2015  (陈彦,瞿鼎,王小宁,张振海,刘聪燕,贾晓斌,周静,范晨怡);

[5] 瞿鼎(5/8),微乳给药系统改善中药活性组分疗效的基础研究,湖南省中医药和中西医结合学会,2022年湖南省中医药科技奖,一等奖,2022  (向大雄,陈彦,胡雄彬,唐甜甜,瞿鼎,刘玉萍,刘聪燕,龚友兰,吴军勇,李泳江)。


联系方式:

quding1985@hotmail.com



擅长: 1. 中药多组分新型药物递送系统抗肿瘤、抗老年性相关视网膜等疾病的临床前研究;2. 通用型纳米乳剂增溶技术的新药研发与产业化研究;3. 功能化无机纳米粒化学免疫治疗肿瘤的临床/临床前研究。

—— 发表文章 ——

近五年发表文章:(按照参考文献格式列举)

[1] Liu C Su W Jiang X Lv Y Kong F Chen Q Zhang Q Zhang H Liu Y Li X Xu X Chen Y* Qu D*. A Sustainable Retinal Drug Codelivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms. Adv Healthc Mater. 2024;22:e2303659.

[2] Jiachen Shi Qiuling Ma Wenting Su Congyan Liu Huangqin Zhang Yuping Liu Xiaoqi Li Xi Jiang Chang Ge Fei Kong Yan Chen Ding Qu*. Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering. Biomaterials Research. 2023;27(1):48.

[3] Tingting Liu Tao Han Congyan Liu Chang Ge Xi Jiang Yuping Liu Fei Kong Xiangyu Su Jiachen Shi Wenting Su Xiaoqi Li Yan Chen  Huangqin Zhang Qiuling Ma Ding Qu*. Polyporus umbellatus polysaccharide iron-based nanocomposite for synergistic M1 polarization of TAMs and combinational anti-breast cancer therapy. International Journal of Biological Macromolecules. 2023;251:126323.

[4] Xinyu Fan Jiachen Shi Ye Liu Mengqiu Zhang Min Lu* Ding Qu*. Cannabidiol-decorated berberine-loaded microemulsions improve IBS-D therapy through ketogenic diet-induced cannabidiol receptors overexpression. International Journal of nanomedicine. 2023;18:2839-2853.

[5] Wenting Su Congyan Liu Xi Jiang Yanli Lv Qin Chen Jiachen Shi Huangqin Zhang Qiuling Ma Chang Ge Fei Kong Xiaoqi Li Yuping Liu Yan Chen Ding Qu*. An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD. J Nanobiotechnology. 2023 21(1):71.

[6] Jian Guo Huating Zeng Xinmeng Shi Tao Han Yimin Liu Yuping Liu Congyan Liu Ding Qu(*) Yan Chen(*). A CFH peptide-decorated liposomal oxymatrine inactivates cancer-associated fibroblasts of hepatocellular carcinoma through epithelial-mesenchymal transition reversion [J]. J Nanobiotechnology 2022 20(1):114.

[7] Zuo Z Li M Han T Zheng X Yao W Wang H Li X(*) Qu D(*). A platelet-cloaking tetramethylprazine-loaded microemulsion for improved therapy of myocardial ischaemia/reperfusion injury. J Drug Target. 2022 30(6):646-656.

[8] Tao Y(#) Qu D(#) Tian C Huang Y Xue L Ju C Hao M(*) Zhang C(*). Modular synthesis of amphiphilic chitosan derivatives based on copper-free click reaction for drug delivery. Int J Pharm. 2021;605:120798.

[9] Ding Qu(*) Yue Qin Yuping Liu Tingting Liu Congyan Liu Tao Han Yan Chen(*) Chenyao Ma Xiaoqi Liu. Fever-Inducible Lipid Nanocomposite for Boosting Cancer Therapy through Synergistic Engineering of a Tumor Microenvironment. ACS Appl Mater Interfaces. 202012(29):32301-32311.

[10] Yue Qin Liu T Mengfei Guo Yuping Liu Congyan Liu Yan Chen(*) Ding Qu(*). Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy. Biomater Sci. 2020;8(14):3916-3925.

[11] Ding Qu(#) Mengying Jiao(#) Haijiao Lin Chunli Tian Guowei Qu Jingwei Xue Lingjing Xue Caoyun Ju Can Zhang(*). Anisamide-functionalized pH-responsive amphiphilic chitosan-based paclitaxel micelles for sigma-1 receptor targeted prostate cancer treatment. Carbohydrate Polymers. 2020 1;229:115498.

[12] Ding Qu Lixiang Wang Yue Qin Mengfei Guo Jian Guo Mengmeng Huang Yuping Liu Congyan Liu Hui Li Yan Chen(*). Non-triggered sequential-release liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion. Biomaterials Science 2018 6(12): 3284-3299.

[13] Ding Qu Lixiang Wang Meng Liu Shiyang Shen Teng Li Yuping Liu Mengmeng Huang Congyan Liu Yan Chen(*) Ran Mo(*) Oral Nanomedicine based on Multicomponent Microemulsions for Drug-Resistant Breast Cancer Treatment Biomacromolecules 201718(4):1268-1280.

[14] Ding Qu(*) Mengfei Guo Yue Qin Lixiang Wang Bin Zong Yunyan Chen Yan Chen(*) A multicomponent microemulsion using rational combination strategy improves lung cancer treatment through synergistic effects and deep tumor penetration Drug Deliv 2017;24(1):1179-1190.

[15] Ding Qu Mingjian Liu Mengmeng Huang Lixiang Wang Yan Chen(*) Congyan Liu Yuping Liu Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy Int J Nanomedicine 2017 12:2045-2059.

[16] Peng Li Zhou X Ding Qu(*) Mengfei Guo Chenyi Fan Ting Zhou Yi Ling(*) Preliminary study on fabrication characterization and synergistic anti-lung cancer effects of self- assembled micelles of covalently conjugated celastrol-polyethylene glycol-ginsenoside Rh2 Drug Deliv 2017;24(1):834-845.

[17] Xiangyu Su Chao Gao Fangfang Shi Xiaoyao Feng Lin Liu Ding Qu(*) Cailian Wang(*) A microemulsion co-loaded with Schizandrin A-docetaxel enhances esophageal carcinoma treatment through overcoming multidrug resistance Drug Deliv 2017;24(1):10-19.

[18] Ding Qu Wenjie Sun Mingjian Liu Yuping Liu Jing Zhou Yan Chen(*) Bitargeted microemulsions based on coix seed ingredients for enhanced hepatic tumor delivery and synergistic therapyInt J Pharm 2016;503(1-2):90-101.

[19]  Qing Chang Rui Geng Shanzheng Wang Ding Qu(*) Xiangfei Kong(*) DOPA-based paclitaxel-loaded liposomes with modifications of transferrin and alendronate for bone and myeloma targetingDrug Deliv 2016;23(9):3629-3638.

[20] Qu D Xue JW Mo R Ju CY Jin X Zhang C. Extracellular pH-sensitive mixed micelles for prostate tumor targeted anticancer drug delivery. J Control Release. 2015;213:e14. (SI)

[21]  Ding Qu Yihua Ma Wenjie Sun Yan Chen(*) Jing Zhou Congyan Liu Mengmeng Huang Microemulsion-based Synergistic Dual-drug Codelivery System for Enhanced Apoptosis of Tumor CellsInt J Nanomedicine 201510:1173-1187.

[22] Qu D Zhou J Liu CY Chen Y. Multi-functional microemulsion delivery system to overcome tumor multidrug resistance. J Control Release. 2015;213:e27. (SI)

[23] Ding Qu(#) Wenjie Sun(#) Yan Chen(*) Jing Zhou Congyan Liu Synthesis and In Vitro Antineoplastic Evaluation of Silver Nanoparticles Mmediated by Agrimoniae herba Extract Int J Nanomedicine 20149:1871-1882.

[24] Wenjie Sun(#) Ding Qu(#) Yihua Ma Yan Chen(*) Congyan Liu Jing Zhou Enhanced Stability and Antibacterial Efficacy of A Traditional Chinese Medicine-mediated Silver Nanoparticle Delivery System Int J Nanomedicine 20149:5491-5502.

[25]  Ding Qu Junjie He Congyan Liu Jing Zhou Yan Chen(*) Triterpene-loaded Microemulsion Using Coix lacryma-jobi Seed Extract as Oil Phase for Enhanced Antitumor Efficacy: Preparation and In Vivo Evaluation Int J Nanomedicine 20149:109-119.

[26]  Ding Qu Haijiao Lin Nan Zhang Jingwei Xue Can Zhang(*) In Vitro Evaluation on Novel Modified Chitosan for Targeted Antitumor Drug Delivery Carbohydrate Polymers 201392:545-554. 

[27]  秦越王理想郭梦斐 瞿鼎(*) 陈彦(*).雷公藤红素/丹参酮Ⅱ_A磺酸钠共传递脂质体的制备、表征及协同抗乳腺癌研究[J].中草药201849(22):5271-5279.

[28]  刘聪燕 瞿鼎(*) 陈彦(*). 中药活性成分防治年龄相关性黄斑变性的研究进展 [J]. 药学学报,202257(05)1219-1234.

[29]  韩陶 陈彦(*) 瞿鼎(*). 天然多糖及其纳米递药系统调控肿瘤微环境的研究进展 [J]. 药学学报,202156(12) 3212-3223. 

[30]  孔菲;  葛畅;  陈彦;  瞿鼎(*). 铁基纳米材料用于肿瘤免疫调节的研究进展 [J]. 中国医院药学杂志 202343(04) 458-463.


—— 学术兼职 ——

[1]世中联中药制剂委员会常务理事,任期20238-20288

[2]中国民族药学会经皮治疗分会常务理事  任期20234-20274

[3]中国颗粒学会青年理事,任期20241-202611

[4]中华中医药中成药分会委员,任期20216-20256

[5]中华中医药学会李时珍分会第六届委员,任期202010-202410

[6]江苏省颗粒学会理事,任期20241-202611

[7]江苏省中西医学会中西医结合治疗分委会委员,任期20233-20263

[8]《针灸与草药(英文)》青年编委 任期20234-20254

[9]“Brain-X”特约编辑,任期20231-202412

[10]《中草药》青年编委,任期202310-202510

[11]《中国医院药学杂志》青年编委

[12]《中国中药杂志》独立审稿人;“Journal of Controlled Release” 独立审稿人;“Acta Biomaterialia” 独立审稿人;“ACS Applied Materials&Interfaces” 独立审稿人;“Advanced Healthcare Materials” 独立审稿人;“Advanced Functional Materials” 独立审稿人